Delirium Bibliography

The searchable delirium bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons.  The HELP team keeps it updated for you on a monthly basis!  Feel free to search by author, title, keywords. It is primarily intended for clinicians and researchers interested in exploring these topics.

Each article is indexed by keywords taken from MEDLINE and other relevant databases.

You may base your search on as many search terms as you like. A search term can be a keyword, an author's name, all or part of an article's title, or any word or phrase that you might expect to find in an article's abstract. You may then indicate whether you would like to limit the search to one or more options.

The results are prioritized so that entries including all search terms will be listed first, but you can indicate whether to then sort by title (the default), by author, by journal name or by publication year.

You may further restrict to a topic category. Note: If you do not enter any search terms, the results will include all of the entries for the selected topic category.

More information about each entry on this page is available by moving the mouse over the green information symbols.

Please note that Pub Med Central (PMC) full text links are provided wherever available.  However, due to copyright restrictions, only abstracts can be provided for articles not available in PMC.

Total Results: 2181

  • Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of a susceptibility score based on factors identified externally in pooled data for use at entry to the acute care pathway. 2017 Pendlebury ST, Lovett NG, Smith SC, Wharton R, Rothwell PM. Age and ageing, 46:2 (226-231)
    • Title

      Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of a susceptibility score based on factors identified externally in pooled data for use at entry to the acute care pathway.

    • Authors
      Pendlebury ST, Lovett NG, Smith SC, Wharton R, Rothwell PM
    • Year
      2017
    • Journal
      Age and ageing
    • URL
    • Abstract
      recognition of prevalent delirium and prediction of incident delirium may be difficult at first assessment. We therefore aimed to validate a pragmatic delirium susceptibility (for any, prevalent and incident delirium) score for use in front-line clinical practice in a consecutive cohort of older acute medicine patients.
    • PubMed ID
  • Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. 2017 Jablonski J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND. Dimensions of critical care nursing : DCCN, 36:3 (164-173)
    • Title

      Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence.

    • Authors
      Jablonski J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND
    • Year
      2017
    • Journal
      Dimensions of critical care nursing : DCCN
    • URL
    • Abstract
      Societal guidelines exist for the management of pain, agitation, and delirium (PAD) in critically ill patients. This contemporary practice aims for a more awake and interactive patient. Institutions are challenged to translate the interrelated multivariable concepts of PAD into daily clinical practice and to demonstrate improvement in quality outcomes. An interdisciplinary goal-directed approach shows outcomes in high-acuity surgical critical care during the early stages of implementation.
    • PubMed ID
  • Delirium in the acute phase after stroke: comparison between methods of detection. 2017 Infante MT, Pardini M, Balestrino M, Finocchi C, Malfatto L, Bellelli G, Mancardi GL, Gandolfo C, Serrati C. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,
    • Title

      Delirium in the acute phase after stroke: comparison between methods of detection.

    • Authors
      Infante MT, Pardini M, Balestrino M, Finocchi C, Malfatto L, Bellelli G, Mancardi GL, Gandolfo C, Serrati C
    • Year
      2017
    • Journal
      Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
    • URL
    • Abstract
      Delirium is an acute neuropsychiatric syndrome, very common in hospitalized people with medical and neurological conditions. The identification of delirium after stroke is not an easy task and validated psychometric instruments are needed to correctly identify it. We decided to verify if (1) formal training in DSM-V criteria is needed to correctly identify post-stroke delirium, (2) if the use of a brief psychometric instrument such as 4AT improves its identification, (3) the applicability of these scales in the stroke setting. In the first phase of this study we retrospectively studied 102 acute stroke patients in Stroke Units of San Martino Hospital (Genova, Italy) to evaluate delirium with clinical criteria, first by a neurologist without a formal training in DSM-V criteria and after training. Then, we enrolled 100 new acute stroke patients who underwent screening for delirium using 4AT scale and DSM-V criteria. In the first phase, DSM-V criteria training significantly increased the ability to capture delirium (5 vs. 15%). In the second phase, the 4AT was used for delirium screening revealing a 52% of cases of delirium, the same observed by the consensus diagnosis of two senior neurologists (that was 50%). In the second phase, the use of 4AT scale allowed to capture post-stroke delirium as well as the consensus diagnosis by two neurologists. The identification of post-stroke delirium is not an easy task and requires both formal training in DSM-V criteria as well as the application of brief scales, such as the 4AT.
    • PubMed ID
  • Progressive brain atrophy and cognitive decline along with multiple episodes of delirium. 2017 Hayakawa K, Kato TA, Imamura S, Kasai N, Kanba S. Psychiatry and clinical neurosciences,
    • Title

      Progressive brain atrophy and cognitive decline along with multiple episodes of delirium.

    • Authors
      Hayakawa K, Kato TA, Imamura S, Kasai N, Kanba S
    • Year
      2017
    • Journal
      Psychiatry and clinical neurosciences
    • URL
    • Abstract
    • PubMed ID
  • Case of insulinoma manifesting as hyperinsulinemia after discontinuing quetiapine in an elderly patient with delirium. 2017 Yamamoto N, Oh E, Nishiyama K, Yoshida M, Saeki A, Ishii H, Takeda Y, Hamahata T, Sugino M. Geriatrics & gerontology international, 17:5 (849-851)
    • Title

      Case of insulinoma manifesting as hyperinsulinemia after discontinuing quetiapine in an elderly patient with delirium.

    • Authors
      Yamamoto N, Oh E, Nishiyama K, Yoshida M, Saeki A, Ishii H, Takeda Y, Hamahata T, Sugino M
    • Year
      2017
    • Journal
      Geriatrics & gerontology international
    • URL
    • Abstract
    • PubMed ID
  • A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China. 2017 Wang J, Peng ZY, Zhou WH, Hu B, Rao X, Li JG. Chinese medical journal, 130:10 (1182-1188)
    • Title

      A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China.

    • Authors
      Wang J, Peng ZY, Zhou WH, Hu B, Rao X, Li JG
    • Year
      2017
    • Journal
      Chinese medical journal
    • URL
    • Abstract
      The management of pain, agitation, and delirium (PAD) in Intensive Care Unit (ICU) is beneficial for patients and makes it widely applied in clinical practice. Previous studies showed that the clinical practice of PAD in ICU was improving; yet relatively little information is available in China. This study aimed to investigate the practice of PAD in ICUs in China.
    • PubMed ID
  • High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery. 2017 Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER. Journal of the American Geriatrics Society,
    • Title

      High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery.

    • Authors
      Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER
    • Year
      2017
    • Journal
      Journal of the American Geriatrics Society
    • URL
    • Abstract
      To examine associations between the inflammatory marker C-reactive protein (CRP) measured preoperatively and on postoperative day 2 (POD2) and delirium incidence, duration, and feature severity.
    • PubMed ID
  • Interventions to Reduce Postoperative Delirium: Aligning Surgical Care With Patients' Needs and Priorities. 2017 Suwanabol PA, Hinshaw DB. JAMA surgery,
    • Title

      Interventions to Reduce Postoperative Delirium: Aligning Surgical Care With Patients' Needs and Priorities.

    • Authors
      Suwanabol PA, Hinshaw DB
    • Year
      2017
    • Journal
      JAMA surgery
    • URL
    • Abstract
    • PubMed ID
  • Assessment of Delirium in Intensive Care Unit Patients: Educational Strategies. 2017 Smith JM, Van Aman MN, Schneiderhahn ME, Edelman R, Ercole PM. Journal of continuing education in nursing, 48:5 (239-244)
    • Title

      Assessment of Delirium in Intensive Care Unit Patients: Educational Strategies.

    • Authors
      Smith JM, Van Aman MN, Schneiderhahn ME, Edelman R, Ercole PM
    • Year
      2017
    • Journal
      Journal of continuing education in nursing
    • URL
    • Abstract
      Delirium is an acute brain dysfunction associated with poor outcomes in intensive care unit (ICU) patients. Critical care nurses play an important role in the prevention, detection, and management of delirium, but they must be able to accurately assess for it. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) instrument is a reliable and valid method to assess for delirium, but research reveals most nurses need practice to use it proficiently.
    • PubMed ID
  • Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review. 2017 Schreuder L, Eggen BJ, Biber K, Schoemaker RG, Laman JD, de Rooij SE. Brain, behavior, and immunity, (362-381)
    • Title

      Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review.

    • Authors
      Schreuder L, Eggen BJ, Biber K, Schoemaker RG, Laman JD, de Rooij SE
    • Year
      2017
    • Journal
      Brain, behavior, and immunity
    • URL
    • Abstract
      Delirium is a frequent outcome for aged and demented patients that suffer a systemic inflammatory insult. Animal models that reconstruct these etiological processes have potential to provide a better understanding of the pathophysiology of delirium. Therefore, we systematically reviewed animal studies in which systemic inflammation was superimposed on aged or diseased animal models. In total, 77 studies were identified. Aged animals were challenged with a bacterial endotoxin in 29 studies, 25 studies superimposed surgery on aged animals, and in 6 studies a bacterial infection, Escherichia coli (E. coli), was used. Diseased animals were challenged with a bacterial endotoxin in 15 studies, two studies examined effects of the cytokine IL-1β, and one study used polyinosinic:polycytidilic acid (poly I:C). This systematic review analyzed the impact of systemic inflammation on the production of inflammatory and neurotoxic mediators in peripheral blood, cerebrospinal fluid (CSF), and on the central nervous system (CNS). Moreover, concomitant behavioral and cognitive symptoms were also evaluated. Finally, outcomes of behavioral and cognitive tests from animal studies were compared to features and symptoms present in delirious patients.
    • PubMed ID
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