Delirium Bibliography

The searchable delirium bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons.  The HELP team keeps it updated for you on a monthly basis!  Feel free to search by author, title, keywords. It is primarily intended for clinicians and researchers interested in exploring these topics.

Each article is indexed by keywords taken from MEDLINE and other relevant databases.

You may base your search on as many search terms as you like. A search term can be a keyword, an author's name, all or part of an article's title, or any word or phrase that you might expect to find in an article's abstract. You may then indicate whether you would like to limit the search to one or more options.

The results are prioritized so that entries including all search terms will be listed first, but you can indicate whether to then sort by title (the default), by author, by journal name or by publication year.

You may further restrict to a topic category. Note: If you do not enter any search terms, the results will include all of the entries for the selected topic category.

More information about each entry on this page is available by moving the mouse over the green information symbols.

Please note that Pub Med Central (PMC) full text links are provided wherever available.  However, due to copyright restrictions, only abstracts can be provided for articles not available in PMC.

Total Results: 2543

  • Association between delirium and death in AIDS patients. 2000 Uldall KK, Ryan R, Berghuis JP, Harris VL. AIDS patient care and STDs, 14:2 (95-100)
    • Title

      Association between delirium and death in AIDS patients.

    • Authors
      Uldall KK, Ryan R, Berghuis JP, Harris VL
    • Year
      2000
    • Journal
      AIDS patient care and STDs
    • URL
    • Abstract
      The purpose of this study was to examine the relationship between delirium and death in AIDS patients. Forty-one patients admitted to a combination skilled nursing and assisted-living facility in 1994 were included in the retrospective chart review. Patients were grouped according to the presence versus absence of delirium during the first week of admission. Demographic characteristics and medical morbidity of the two groups were compared using the Chi-square statistic. Kaplan-Meier survival analysis was used to estimate survival functions during the study period for the delirious and nondelirious groups. Nine patients (22%) were found to have an episode of delirium in the first week of admission. There were no significant differences in demographic characteristics or medical morbidity between the delirious and nondelirious groups. Median days from admission to death for those with delirium (10 days) versus those without delirium (135 days) was significantly different (log rank = 19.03; p < 0.0001). Authors concluded that delirium is a marker for decreased survival in this sample of AIDS patients. Future research needs to demonstrate whether improved care of AIDS patients can prevent delirium or limit adverse outcomes associated with it.
    • PubMed ID
  • Temporal association between hospitalization and rate of falls after discharge. 2000 Mahoney JE, Palta M, Johnson J, Jalaluddin M, Gray S, Park S, Sager M. Archives of internal medicine, 160:18 (2788-95)
    • Title

      Temporal association between hospitalization and rate of falls after discharge.

    • Authors
      Mahoney JE, Palta M, Johnson J, Jalaluddin M, Gray S, Park S, Sager M
    • Year
      2000
    • Journal
      Archives of internal medicine
    • URL
    • Abstract
      Evidence suggests that acute illness and hospitalization may increase the risk for falls.
    • PubMed ID
  • Consequences of not recognizing delirium superimposed on dementia in hospitalized elderly individuals. 2000 Fick D, Foreman M. Journal of gerontological nursing, 26:1 (30-40)
    • Title

      Consequences of not recognizing delirium superimposed on dementia in hospitalized elderly individuals.

    • Authors
      Fick D, Foreman M
    • Year
      2000
    • Journal
      Journal of gerontological nursing
    • URL
    • Abstract
      The purpose of this study was to describe the recognition and management of delirium in hospitalized patients with and without dementia.
    • PubMed ID
  • The cause of delirium in patients with hip fracture. 2000 Brauer C, Morrison RS, Silberzweig SB, Siu AL. Archives of internal medicine, 160:12 (1856-60)
    • Title

      The cause of delirium in patients with hip fracture.

    • Authors
      Brauer C, Morrison RS, Silberzweig SB, Siu AL
    • Year
      2000
    • Journal
      Archives of internal medicine
    • URL
    • Abstract
      To ascertain the most common causes of delirium, to establish the initiation and timing of delirium, and to determine the duration of delirium in patients with hip fracture.
    • PubMed ID
  • Large neutral amino acid changes and delirium in febrile elderly medical patients. 2000 Flacker JM, Lipsitz LA. The journals of gerontology. Series A, Biological sciences and medical sciences, 55:5 (B249-52; discussion B253-4)
    • Title

      Large neutral amino acid changes and delirium in febrile elderly medical patients.

    • Authors
      Flacker JM, Lipsitz LA
    • Year
      2000
    • Journal
      The journals of gerontology. Series A, Biological sciences and medical sciences
    • URL
    • Abstract
      A hypothesized but unexplored mechanism for delirium in older persons is that changes in plasma large neutral amino acid (LNAA) concentrations alter brain serotonin levels, result in neurotoxicity, or both. Therefore we performed a prospective study of 21 acutely febrile long-term-care residents to study the relationship between LNAA changes and delirium. Plasma LNAA concentrations were evaluated during illness and 1 month later. Delirium was diagnosed by using the Confusion Assessment Method. Other data included age, body mass index, cognitive impairment, comorbidity, gender, maximum temperature, and medication use. Seven subjects (33%) were delirious during febrile illness. Although the phenylalanine (PHE)/LNAA ratio was higher during illness in both delirious and nondelirious groups, a two-sample t test demonstrated that delirium was associated with a higher illness PHE/LNAA ratio (p = .03). The amount of change in PHE/LNAA from illness to recovery was not different between the delirious and nondelirious groups. Tryptophan/LNAA was not associated with delirium during illness or at recovery. These findings identify another potentially fruitful area of investigation for the prevention and treatment of delirium in older persons.
    • PubMed ID
  • The role of the advanced practice nurse in facilitating a clinical research study. Screening for delirium. 2000 Lacko LA, Dellasega C, Salerno FA, Singer H, DeLucca J, Rothenberger C. Clinical nurse specialist CNS, 14:3 (110-5; quiz 116-8)
    • Title

      The role of the advanced practice nurse in facilitating a clinical research study. Screening for delirium.

    • Authors
      Lacko LA, Dellasega C, Salerno FA, Singer H, DeLucca J, Rothenberger C
    • Year
      2000
    • Journal
      Clinical nurse specialist CNS
    • URL
    • Abstract
      As advanced practitioners, clinical nurse specialists and nurse practitioners have a leadership role in integrating and promoting nursing research in clinical settings. In this quasi-experimental study, the role of the advanced practice nurse in developing and implementing an intervention that improved delirium screening by staff nurses is described. Screening practices of the treatment group nurses were accurate in 100% of the cases. Control nurses failed to detect any cases of delirium. A discussion of study findings and their relevance to advanced practice nursing are discussed.
    • PubMed ID
  • A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture. 2000 Morrison RS, Siu AL. Journal of pain and symptom management, 19:4 (240-8)
    • Title

      A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture.

    • Authors
      Morrison RS, Siu AL
    • Year
      2000
    • Journal
      Journal of pain and symptom management
    • URL
    • Abstract
      Advanced dementia patients may be at substantial risk for undetected or undertreated pain. To examine the treatment of pain following hip fracture, a prospective cohort study was conducted in an academic teaching hospital. Fifty-nine cognitively intact elderly patients with hip fracture and 38 patients with hip fracture and advanced dementia were assessed daily. The cognitively intact patients rated their pain on a numeric scale ranging from 0 (none) to 4 (very severe). Analgesics prescribed and administered were recorded and compared to hip fracture patients with advanced dementia. The advanced dementia patients received one-third the amount of morphine sulfate equivalents as the cognitively intact patients. Forty-four percent of cognitively intact individuals reported severe to very severe pain preoperatively and 42% reported similar pain postoperatively. Half the cognitively intact patients who experienced moderate to very severe pain were prescribed inadequate analgesia for their level of pain. Eighty-three percent of cognitively intact patients and 76% of dementia patients did not receive a standing order for an analgesic agent. These data reveal that a majority of elderly hip fracture patients experienced undertreated pain. The fact that advanced dementia patients received one-third the amount of opioid analgesia as compared to cognitively intact subjects-40% of whom reported severe pain postoperatively-suggests that the majority of dementia patients were in severe pain postoperatively. This study and others suggest that directed interventions to improve pain detection and alter physician prescribing practices in the cognitively impaired are needed.
    • PubMed ID
  • Prevalence and detection of delirium in elderly emergency department patients. 2000 Elie M, Rousseau F, Cole M, Primeau F, McCusker J, Bellavance F. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 163:8 (977-81)
    • Title

      Prevalence and detection of delirium in elderly emergency department patients.

    • Authors
      Elie M, Rousseau F, Cole M, Primeau F, McCusker J, Bellavance F
    • Year
      2000
    • Journal
      CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
    • URL
    • Abstract
      Delirium is a complex medical disorder associated with high morbidity and mortality among elderly patients. The goals of our study were to determine the prevalence of delirium in emergency department (ED) patients aged 65 years and over and to determine the sensitivity and specificity of a conventional clinical assessment by an ED physician for the detection of delirium in the same population.
    • PubMed ID
  • The bedside confusion scale: development of a portable bedside test for confusion and its application to the palliative medicine population. 2000 Stillman MJ, Rybicki LA. Journal of palliative medicine, 3:4 (449-56)
    • Title

      The bedside confusion scale: development of a portable bedside test for confusion and its application to the palliative medicine population.

    • Authors
      Stillman MJ, Rybicki LA
    • Year
      2000
    • Journal
      Journal of palliative medicine
    • URL
    • Abstract
      Clinical tests for confusion in medically ill patients are frequently burdensome and difficult to use. Available tests lack portability and tend to be shunned in clinical practice by physicians.
    • PubMed ID
  • Development and validation of a brief observer-rated screening scale for depression in elderly medical patients. 2000 Hammond MF, O'Keeffe ST, Barer DH. Age and ageing, 29:6 (511-5)
    • Title

      Development and validation of a brief observer-rated screening scale for depression in elderly medical patients.

    • Authors
      Hammond MF, O'Keeffe ST, Barer DH
    • Year
      2000
    • Journal
      Age and ageing
    • URL
    • Abstract
      to develop a depression screening scale that does not rely on verbal communication.
    • PubMed ID
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