Delirium Bibliography

**The Delirium Bibliography is moving!**

 

We're excited to announce that the Delirium Bibliography has been moved to the Network for Investigation of Delirium: Unifying Scientists (NIDUS) website! The new bibliography includes well over 3,000 references on delirium and acute care for elders in addition to new references on pediatric delirium, as well. Articles in the new bibliography are still indexed by keywords taken from MEDLINE and other relevant databases, and they can be easily browsed with a search function. Questions? Email margaretwebb@hsl.harvard.edu

The searchable delirium bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons.  The HELP team keeps it updated for you on a monthly basis!  Feel free to search by author, title, keywords. It is primarily intended for clinicians and researchers interested in exploring these topics.

Each article is indexed by keywords taken from MEDLINE and other relevant databases.

You may base your search on as many search terms as you like. A search term can be a keyword, an author's name, all or part of an article's title, or any word or phrase that you might expect to find in an article's abstract. You may then indicate whether you would like to limit the search to one or more options.

The results are prioritized so that entries including all search terms will be listed first, but you can indicate whether to then sort by title (the default), by author, by journal name or by publication year.

You may further restrict to a topic category. Note: If you do not enter any search terms, the results will include all of the entries for the selected topic category.

More information about each entry on this page is available by moving the mouse over the green information symbols.

Please note that Pub Med Central (PMC) full text links are provided wherever available.  However, due to copyright restrictions, only abstracts can be provided for articles not available in PMC.

Total Results: 3263

  • Cortisol response to surgery and postoperative confusion in depressed patients under general anesthesia with fentanyl. 2002 Kudoh A, Takahira Y, Katagai H, Takazawa T. Neuropsychobiology, 46:1 (22-6)
    • Title

      Cortisol response to surgery and postoperative confusion in depressed patients under general anesthesia with fentanyl.

    • Authors
      Kudoh A, Takahira Y, Katagai H, Takazawa T
    • Year
      2002
    • Journal
      Neuropsychobiology
    • URL
    • Abstract
      The purpose of this study was to investigate the relationship between postoperative confusion and plasma cortisol response to surgery in depressed patients. We studied 80 depressed patients and 40 control patients who had undergone orthopedic surgery and perioperatively measured plasma cortisol and adrenocorticotropin levels. Postoperative confusion in the first 3 postoperative days occurred in 5 (13%) depressed patients given fentanyl during anesthesia, 13 (33%) patients without fentanyl and 1 (3%) control patients. Plasma cortisol concentration (19.7 +/- 6.9 and 19.2 +/- 8.0 microg dl(-1)) 15 min after skin incision and 60 min after the end of surgery in depressed patients with fentanyl was significantly lower than that (24.2 +/- 7.2 and 23.5 +/- 8.1 microg dl(-1)) of depressed patients without fentanyl. Plasma cortisol levels during and after surgery in depressed patients with postoperative confusion were higher than those of depressed patients without postoperative confusion. We conclude that the occurrence of postoperative confusion in depressed patients is associated with an increase in plasma cortisol levels during and after surgery. The incidence of postoperative confusion in depressed patients with fentanyl was significantly lower than that of depressed patients without fentanyl.
    • PubMed ID
  • Schizophrenic patients who develop postoperative confusion have an increased norepinephrine and cortisol response to surgery. 2002 Kudoh A, Takahira Y, Katagai H, Takazawa T. Neuropsychobiology, 46:1 (7-12)
    • Title

      Schizophrenic patients who develop postoperative confusion have an increased norepinephrine and cortisol response to surgery.

    • Authors
      Kudoh A, Takahira Y, Katagai H, Takazawa T
    • Year
      2002
    • Journal
      Neuropsychobiology
    • URL
    • Abstract
      The purpose of this study was to investigate the relationship between postoperative confusion and the plasma norepinephrine (NE), adrenocorticotropin (ACTH) or cortisol response to surgery in schizophrenic patients. We studied 50 schizophrenic patients and 35 control patients who underwent orthopedic surgery and perioperatively measured plasma NE, ACTH and cortisol levels. Postoperative confusion during 72 h after the end of the operation occurred in 14 of 50 schizophrenic patients (28%) and in 2 of 35 control patients (6%). Plasma NE levels 15 min after skin incision, the next day, the second day and the third day after operation in schizophrenic patients with postoperative confusion (668.0 +/- 59.2, 522.0 +/- 96.5, 463.2 +/- 71.2 and 398.9 +/- 56.2 pg/ml, respectively) were significantly higher than those in schizophrenic patients without confusion (524.1 +/- 62.6, 342.4 +/- 38.6, 311.2 +/- 58.3 and 314.1 +/- 77.1 pg/ml, respectively). Plasma cortisol levels 15 min after the skin incision and the next and second days after operation in schizophrenic patients with postoperative confusion (23.6 +/- 3.2, 21.1 +/- 4.3 and 19.9 +/- 4.4 microg/dl, respectively) were significantly higher than those in schizophrenic patients without confusion (15.2 +/- 4.5, 14.3 +/- 5.1 and 13.8 +/- 3.8 microg/dl, respectively). In conclusion, the occurrence of postoperative confusion in schizophrenic patients is associated with an increase in plasma norepinephrine and cortisol levels during and after surgery.
    • PubMed ID
  • Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients. 2002 Kudoh A, Katagai H, Takazawa T. Journal of clinical anesthesia, 14:2 (107-10)
    • Title

      Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients.

    • Authors
      Kudoh A, Katagai H, Takazawa T
    • Year
      2002
    • Journal
      Journal of clinical anesthesia
    • URL
    • Abstract
      To investigate whether total IV anesthesia with ketamine, propofol, and fentanyl affects the frequency of postoperative psychosis emergence or confusion in schizophrenic patients.
    • PubMed ID
  • Small-dose ketamine improves the postoperative state of depressed patients. 2002 Kudoh A, Takahira Y, Katagai H, Takazawa T. Anesthesia and analgesia, 95:1 (114-8, table of contents)
    • Title

      Small-dose ketamine improves the postoperative state of depressed patients.

    • Authors
      Kudoh A, Takahira Y, Katagai H, Takazawa T
    • Year
      2002
    • Journal
      Anesthesia and analgesia
    • URL
    • Abstract
      We investigated whether ketamine is suitable for depressed patients who had undergone orthopedic surgery. We studied 70 patients with major depression and 25 patients as the control (Group C). The depressed patients were divided randomly into two groups; patients in Group A (n = 35) were induced with propofol, fentanyl, and ketamine and patients in Group B (n = 35) were induced with propofol and fentanyl, and all patients were maintained with 1.5%-2.0% isoflurane plus nitrous oxide. The mean Hamilton Depression Rating (HDR) score was 12.7 +/- 5.4 for Group A and 12.3 +/- 6.0 for Group B 2 days before surgery and 9.9 +/- 4.1 for Group A and 14.4 +/- 3.8 for Group B 1 day after surgery. The HDR score in Group A 1 day after surgery was significantly (P < 0.05) lower than that in Group B. The HDR score in Group C was 4.2 +/- 1.7 2 days before surgery and 4.8 +/- 1.6 1 day after surgery. Depressed mood, suicidal tendencies, somatic anxiety, and hypochondriasis significantly decreased in Group A as compared with Group B. Postoperative pain scores in Group A at 8 and 16 h after the end of anesthesia were 26.6 +/- 8.7 and 24.9 +/- 8.2, respectively, which were significantly (P < 0.05) lower than 34.3 +/- 12.0 and 31.1 +/- 8.8 in Group B. In conclusion, small-dose ketamine improved the postoperative depressive state and relieved postoperative pain in depressed patients.
    • PubMed ID
  • Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia. 2002 Kudoh A, Katagai H, Takazawa T. Canadian journal of anaesthesia = Journal canadien d'anesth├ęsie, 49:2 (132-6)
    • Title

      Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia.

    • Authors
      Kudoh A, Katagai H, Takazawa T
    • Year
      2002
    • Journal
      Canadian journal of anaesthesia = Journal canadien d'anesth├ęsie
    • URL
    • Abstract
      To investigate whether antidepressants administered to patients for chronic depression patients should be continued or discontinued before anesthesia.
    • PubMed ID
  • Preoperative factors associated with postoperative change in confusion assessment method score in hip fracture patients. 2002 Zakriya KJ, Christmas C, Wenz JF, Franckowiak S, Anderson R, Sieber FE. Anesthesia and analgesia, 94:6 (1628-32, table of contents)
    • Title

      Preoperative factors associated with postoperative change in confusion assessment method score in hip fracture patients.

    • Authors
      Zakriya KJ, Christmas C, Wenz JF, Franckowiak S, Anderson R, Sieber FE
    • Year
      2002
    • Journal
      Anesthesia and analgesia
    • URL
    • Abstract
      Postoperative delirium is a major problem in elderly patients undergoing surgical repair of hip fracture. It is imperative to identify potentially treatable preoperative factors associated with the onset of postoperative delirium to optimize outcome. We sought to determine what preoperative variables are associated with postoperative delirium in geriatric patients undergoing surgical repair of hip fracture. In a prospective, IRB-approved study, patients admitted to the geriatric hip fracture service were examined daily in the hospital for the occurrence of postoperative delirium. All patients with a preoperative diagnosis of dementia or delirium were eliminated. A positive confusion assessment method score ([+]CAM) was used to determine the presence of postoperative delirium during the acute hospital stay. To determine the association between preoperative variables (demographics, laboratory values, and comorbidities) and postoperative (+)CAM scores, chi(2) and logistic regression analysis were performed with calculation for the odds ratios (OR). One-hundred-sixty-eight patients (72% women) were included in the analysis. Twenty-eight percent (n = 47) of patients had a (+)CAM score. Three variables were significant predictors of a (+)CAM score: (a) normal white blood cell count (OR, 2.2), (b) abnormal serum sodium (OR, 2.4); and (c) ASA physical status >II (OR, 11.3). The results suggest that preoperative medical conditions (abnormal serum sodium and ASA physical status >II) and an inability to mount a stress response (normal white blood cell count) may influence the patient's postoperative mental status. In particular, two of the risk factors we identified may be amenable to therapy and are abnormal serum sodium and lack of an increase in white blood cell count during the stress of trauma and surgery.
    • PubMed ID
  • Patients with hip fracture: subgroups and their outcomes. 2002 Eastwood EA, Magaziner J, Wang J, Silberzweig SB, Hannan EL, Strauss E, Siu AL. Journal of the American Geriatrics Society, 50:7 (1240-9)
    • Title

      Patients with hip fracture: subgroups and their outcomes.

    • Authors
      Eastwood EA, Magaziner J, Wang J, Silberzweig SB, Hannan EL, Strauss E, Siu AL
    • Year
      2002
    • Journal
      Journal of the American Geriatrics Society
    • URL
    • Abstract
      To present several alternative approaches to describing the range and functional outcomes of patients with hip fracture.
    • PubMed ID
  • Improving medication use in newly admitted home healthcare patients: a randomized controlled trial. 2002 Meredith S, Feldman P, Frey D, Giammarco L, Hall K, Arnold K, Brown NJ, Ray WA. Journal of the American Geriatrics Society, 50:9 (1484-91)
    • Title

      Improving medication use in newly admitted home healthcare patients: a randomized controlled trial.

    • Authors
      Meredith S, Feldman P, Frey D, Giammarco L, Hall K, Arnold K, Brown NJ, Ray WA
    • Year
      2002
    • Journal
      Journal of the American Geriatrics Society
    • URL
    • Abstract
      To test the efficacy of a medication use improvement program developed specifically for home health agencies. The program addressed four medication problems identified by an expert panel: unnecessary therapeutic duplication, cardiovascular medication problems, use of psychotropic drugs in patients with possible adverse psychomotor or adrenergic effects, and use of nonsteroidal antiinflammatory drugs (NSAIDs) in patients at high risk of peptic ulcer complications. It used a structured collaboration between a specially trained clinical pharmacist and the patients' home-care nurses to improve medication use.
    • PubMed ID
  • A scale for measuring patient perceptions of the quality of end-of-life care and satisfaction with treatment: the reliability and validity of QUEST. 2002 Sulmasy DP, McIlvane JM, Pasley PM, Rahn M. Journal of pain and symptom management, 23:6 (458-70)
    • Title

      A scale for measuring patient perceptions of the quality of end-of-life care and satisfaction with treatment: the reliability and validity of QUEST.

    • Authors
      Sulmasy DP, McIlvane JM, Pasley PM, Rahn M
    • Year
      2002
    • Journal
      Journal of pain and symptom management
    • URL
    • Abstract
      We report on the adaptation and evaluation of a previously developed patient-centered instrument that we call the Quality of End-of-life care and Satisfaction with Treatment (QUEST) scale. In a separate group of 30 inpatients, test-retest reliability for QUEST items ranged from 63% agreement (kappa = 0.43) to 93% agreement (kappa = 0.86) and construct validity was evidenced by correlations with a somewhat related satisfaction scale ranging from 0.38 to 0.47. QUEST was then administered to 206 consecutive medical inpatients (or their surrogates) with DNR orders and to a comparison group of 51 medical inpatients without DNR orders at 2 academic medical centers. Among these main study patients, internal consistency was reflected by Cronbach alphas of 0.88 to 0.93. QUEST scores showed modest inverse correlations with severity of symptoms, but were uncorrelated with severity of illness, anxiety, or depression, suggesting an appropriate relationship to symptom control but divergence of the underlying construct from degree of physical illness or affective state. QUEST scores were lower for patients with DNR orders compared to those without DNR orders (P = 0.02 to 0.06). Surrogate ratings of satisfaction and quality were uncorrelated with patient ratings. Although preliminary, these findings suggest that QUEST may be useful in assessing quality and satisfaction with the care rendered by physicians and nurses to hospitalized patients at the end of life.
    • PubMed ID
  • Patients' ratings of quality and satisfaction with care at the end of life. 2002 Sulmasy DP, McIlvane JM. Archives of internal medicine, 162:18 (2098-104)
    • Title

      Patients' ratings of quality and satisfaction with care at the end of life.

    • Authors
      Sulmasy DP, McIlvane JM
    • Year
      2002
    • Journal
      Archives of internal medicine
    • URL
    • Abstract
      To elicit ratings of quality and satisfaction with care from medical inpatients, especially those near the end of life.
    • PubMed ID
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